It is my great pleasure to inform you of the 14th International Meeting on RNase H, RNaseH2016, to be held in Kyoto from September 6 to 9, 2016.
Ribonuclease H (RNase H) is an enzyme that specifically degrades RNA of RNA/DNA hybrids. RNase H is present ubiquitously in sources ranging from bacteria to human. It has recently been shown that, under physiological conditions, DNA polymerases incorporate a ribonucleotide every few thousand base pairs, and that mutations in human RNase H2 genes lead to a severe neuroinflammatory disorder, Aicardi-Goutières syndrome. Even though the presence of RNase H1 in mitochondria has been known for some time, only recently a mutation in RNase H1 has been reported as a cause of a mitochondrial disorder in a few human patients. Retroviral reverse transcriptase RNase H remains of great importance for its function and as a target for therapeutic drugs for HIV-AIDs.
The purpose of this International Meeting is to discuss recent progress in RNase H and its relating enzymes as well as practical application of the research results in the fields of biology, biochemistry, and medical chemistry. Since the first RNase H meeting (RNaseH1990) in Hawaii, this meeting has been held all over the world every two years. In Japan, the meeting was held in Osaka in 1996 and in Tsuruoka in 2002 and 2008.
We look forward to meeting you in Kyoto.
Executive Committee Chairman, RNaseH2016
Professor, Keio University
- Mitsuhiro Itaya (Chairman; Professor, Keio University, Japan)
- Shigenori Kanaya (Professor Emeritus, Osaka University, Japan)
- Kiyoshi Yasukawa (Secretariat; Professor, Kyoto University, Japan)
- Robert Crouch（Senior Investigator, US National Institutes of Health）